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Arteriosclerotic heart disease

Atherosclerosis

Arteriosclerotic heart disease (ASHDhappens when there is a hardening and thickening of the coronary artery walls. Atherosclerosis develops where there are clogged arteries containing fatty substances known as plaque or atheroma.
Even now the process of Arteriosclerotic heart disease is not fully understood, inflammation plays a big role by retaining low density lipoprotein particles (LDL) in the endothelial cells of the blood vessels wall. This retention could be the beginning, cause or effect of the underlying inflammatory process.

 


Plaque build up

blood vessel wall

Plaque build-up puts pressure on the blood vessels muscle cells which causes them to stretch the additional plaque is the reason the endothelial lining thickens and causes the plaque to separate from the lumen. The arterial wall becomes stiff and the blood doesn’t flow normally.

 

 


Signs and symptoms

Blood supply to the brain and neck flow through the Caratoid arteries, a narrowing of the Caratoid artery can result in symptoms such as feeling weak, difficulty speaking, dizziness, blurred vision, numbness in the face, arms or legs, chronic headache and loss of consciousness. The symptoms of a stroke are caused by an artery narrowing or closing going to the brain, a lack of blood supply kills the cells of the affected tissue.


Peripheral artery disease

Peripheral arteries

Peripheral arteries supply blood to the arms, legs and pelvis area, blood ruptures and clots narrow the arteries, symptoms that follow are pain and numbness in the arms and legs. Plaque will also form in the renal arteries supplying blood to the kidneys which leads a decrease in the kidney blood flow and result in chronic kidney disease.

 


Risk factors

There are a number of risk factors contributing to Arteriosclerotic heart disease

1.Diabetes

2.Trans fats in the food that we eat

3.Smoking

4. Obesity

5. Resistance to insulin

6.High blood pressure

7.Dyslipidemia

8.Western diets


Atheromatous plaque

Arterial plaque build-up

Atheromatous plaque occurs where there is an accumulation of fatty substances known as plaques. It is a slow process which develops over several years due to a complex number of cellular events which occur inside the arterial wall. The endothelial all is under constant attack from monocytes,leucocytes or basophils, this results in inflammation which leads to a formation of atheromatous plaque within the arterial tunica intima.

This is a part of the blood vessel wall situated between the endothelium and the tunic media, this atheromatous plaque consists of fat, elastin and collagen. During this process the plaque grows, the wall thickens but doesn’t narrow until Stenosis occurs later


Stenosis

Stenosis happens where there is severe narrowing,usually detectable after an angiogram is performed,sometimes detected after a stress test.This method has been used for many years to detect severe narrowing but they don’t focus on the underlying problem of atherosclerosis disease.In more recent times human clinical studies have shown where there was a heart attack or stroke heavy plaque build up was present.


Conclusion

Based on what we now know to be the main cause of heart attack or stroke, namely plaque build up in the arterial wall doesn’t it make sense to find out how to remove the plaque associated with  Arteriosclerotic heart disease?

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