Serrapeptase and science- what we know

Serrapeptase benefits

Serrapeptase and science- what we know

Serrapeptase has been around for the last 30 years and is used extensively by health practitioners throughout Europe and Asia, it is classified as a dietary supplement in the United states.

Serrapeptase is used where pain is present in some conditions that include Headache Tension,Migraine,Fibromylgia, Oesteoporosis, Rheumatoid Arthritis, Back pain, Osteoarthritis and back pain.

I think in general we are a bit fed up with over the counter medicines when we read of the potential side effects of NSAIDs if used over a long period of time.

The nutraceutical industry has been searching for years to find a safe natural alternative to NSAIDs for inflammation and pain relief. During the 1970’s a massive discovery was made the enzyme Serra peptidase was found in the intestine of the silkworm and now it is used throughout the world as a safe natural alternative to pain killers like Ibuprofen, aspirin, paracetamol and other more potent NSAIDs.

Benefits of taking Serrapeptase

One of the benefits of taking Serrapeptase is that the gastrointestinal side effects are minimal, without doubt it is attractive alternative to people suffering from swelling, chronic pain and inflammation.

It is used where there is inflammation with good success, conditions like inflammatory bowel disease, ulcerative colitis, sore throat; it is used if a vein is swollen because of a blood clot formation (Thrombophlebitis) also helpful with an ear infection, sore throat,crohn’s disease.

Because Serapeptase has the ability to break up clots it is used to fight heart disease or atherosclerosis which is known as hardening of the arteries.

It has been used for fibrocystic breast disease (non cancerous lumpy breasts)or breast lump infection, some mothers have used it for breast engorgement (breast pain) following pregnancy.

Serrapeptase has been used in the treatment of leg ulcers, asthma, pus accumulation (emphysema) and the treatment of diabetes.

Serrapeptase the enzyme is also known by other names like, serrapeptidase, Serratia E-15, Serraslyin, The various isoforms of this enzyme are isolated from different Serratia strains.

Serrapeptase and your cardiovascular system:

The blood that flows through our veins is carried in small tubes being pumped around the body and containing oxygen, dead material is disposed within the cells and organs. Blood circulation is a vital part of staying well, Blood clots can form over time because of excess fibrin accumulation which can lead to a heart attack or stroke. Even though it is the function of the liver,Serrapeptase can help to digest these clots.

Serraenzyme 80,000-90caps

In this study patients pain had decreased

Esch PM ,

Gerngross H ,

Fabian A 

Fortschritte der Medizin [01 Feb 1989, 107(4):67-8, 71-2]

Type: Clinical Trial, Randomized Controlled Trial, Journal Article, English Abstract (lang: ger)

What are Serrapeptidase uses:

Serrapeptidase or Serrapeptase is known to be an enzyme taken from the intestine of the silkworm,In Europe they market it under the name Anaflazyme,in Asia it is sold under the brand name Danzen.

It has many uses in a clinical setting:

It is used to treat inflammation,especially where there is swelling.

It has been used in the treatment of Fibrocystic breast disease.

It has been used for treating sinusitis and skin problems.

It has been used to reduce cholesterol and remove plaque in the arterial system.

It has been used for pain relief, for example arthritis.polymyalgia.

It has been used to relieve bronchitis,because it expels and loosens mucus.

It has been used to treat varicose veins.

SerraEnzyme 250K -30Caps

We know that Serrapeptase can digest dead tissue without harming good tissue,It can also digest cysts,arterial plaque,blood clots. Dr Hans Napier, the late German physician did use Serrapeptase in treating arterial plaque blockages in his patients,so we could describe the enzyme as Doctor best Serrapeptase because of it’s health benefits.

Serrapeptase references:

1 Kee..Selan L, Berlutti F, Passariello C. Comodi-Ballanti MR, Thaller MC. Proteolytic enzymes: a new treatment strategy for prosthetic infections – Antimicrob Agents Chemother. 1993; 37(12):26l8-21.

2. Majima Y, Inagaki M, Hirata K. Takeuchi K, Morishita A, Sakakura Y. The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988;244(6):355-9.

3. Esch PM, Gemgross H. Fabian A. Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase-a prospective study (German). FortschrMed. 1989; 107(4):67-8, 71-2.

4. Aso T. et al. Breast engorgement and its treatment: Clinical effects of Danzen (serrapeptase) an anti-inflammatory enzyme preparation. The world of Obstetrics and Gynecology (Japanese). 1981:33:371-9.

5. Miyata, K. Intestinal absorption of serrapeptase. J ApplBiochem. 1980:2:111-16.

6. Majima. Y. et al. Effects of orally administered drugs on dynamic viscoelasticity of human nasal mucus. Am. Rev. Respir. Dis. 141:79-83.1990

7. Marriott, C. Modification of the rheoloaical properties of mucus by drugs. Adv. Exp. Med. Biol. 144^75-84, 1982

8. Kase, Y. et al. A new method for evaluating mucolytic expectorant activity and its application. II. Application to two proteolytic enzymes, serrapeptase and seaprose. Arzneimittelforschung 32:374-378,1982.

9. Tomoda, K. and Miyatam K. Some information on the composition of tracheal secretions before and after the administration of serrapeptase. Exper. Ther. 477:9-16, 1972

10. Tago. T. and Mitsui, S. Effects of serrapeptase in dissolution of sputum, especially in patients with bronchial asthma. Jap. Clin. Exp. Med. 49:222-228, 1972

11. Fujitani., T. et al. Effect of anti-inflammatory agent on transfer of antibiotics to the maxillary sinus mucosa in chronic sinusitis. Otorhinolaryngol. Clin. North Am. 66:557-565. 1976

12. Perna, L. Osservazioni cliniche sul trattamento in doppio cieco con Serratio peptidasi, nella rinite perenne nella rinitie cronica riacutizzata con sinusopatia. nella bronchite cronica riacutizzata. Riv. Pat. Clin.Tuberc. Penumol. 56:509-516,1985

13. Matsudo, A. et at. Effect of serrapeptase (Danzen) on inflammatory edema following operation for thyropid disease. Med. Consult. New Remedy 18:171-175, 1981

14. Harada, Y. Clinical efficacy of serrapeptase on buccal swelling after radical operation for chronic sinusitis. Igaku Ayumi 123:768-778.1982

15. Elies, W. et al. Akute und subakute Entzundungen der Nassenbenholen. Z. Allmeinmed. 4:92-95, 1987.

16. Yamazaki, J. et al. Anti-inflammatory activity of TSP, a protease produced by a strain of Serratia. Folia Pharmacol. Japon. 6^302-314,1967.

17. Odagiri., J. et al. Clinical applications of serrapeptase in sinusitis. Med. Consult. New Remedy 6:201-209, 1979

18. Marly, M. Enzymothe rapie anti-inflammatoire a l’aide de la serrapeptase: resultats cliniques en traumatologie et en ORL. C RTherapeut. 3:9-19,1985

19. Kakinumu., A. et al. Regression of fibrinolysis in scalded rats by administration of serrapeptase. Biochem. Pharmacol. 31:2861-2866,1982

20. Pallotti., S. et al. Valutazu-one della’attivita fibrinolytica della serrapeptase. Farmaci 3:163-173,1982

21. Conticello, S. et al. La serrapeptase in ORL Nuova Clin. ORL 31:15-20,1979.

22. Mazzonie, A. et al. Evaluation of serrapeptase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind randomized trial versus placebo. J. int. Med. Res. 18(5):379-388,1990

23. Braga, P.C. et al. Effects of serrapeptase on muco-ciliary clearance in patients with chronic bronchitis. Curr. Ther. Res. 29(5):738-744,1981

24. Carratu, L. et al. Physio-chemical and rheological research on mucolytic activity of serrapeptase in chronic broncho-pneumopathies. Curr.Ther. Res. 28(6):937-951. 1980

25. Mizukoshi, D. et al. A double-blind clinical study of serrapeptase in the treatment of chronic sinusitis. Igaku Ayrni 109:50-62.1979

26. WH. Tan SL, Lee V. Salmon YM. The treatment of breast engorgement with Serrapeptase (Danzen): a randomized double-blind controlled trial. Singapore Med J. 1989:30(l):48-54


 Serratiopeptidase an alternate anti-inflammatory drug

Serratiopeptidase is widely used in medicine; it has a long history in fighting different kinds of inflammatory disorders and inflammation. Serrapeptase or Serratiopeptidase is a protein (proteolytic) enzyme which is isolated from the non-pathogenic enterobacteria Serratia E15 that is found in silkworms. It is prescribed as an anti inflammatory pain relief in surgery, otorhinolaryngology, gynecology, orthopedics, and dentistry. In recent years research has shown that Serrapeptase is most effective in treating atherosclerosis, similiar to many enzymes, Serrapeptase has affinity to substrate and reports suggest it to be useful managing inflammation and pain.

In 2015 Chappi, conducted post op research, the conclusion methylprednisolone had better pain relief but serratiopeptidase exerted anti swelling and better anti inflammatory effects foll.Furthermore, a synergistic combination of Serrapeptase and methylprednisolone proved more effective when expected post op sequale materialized. More on this click here 


A study in 2014 found that by using Serratiopeptidase and periodontal a solution for enhanced drug delivery was made.

Chitosan nano particles loaded with Serratiopeptidase were found after analysis for an effective anti inflammatory drug used in a variety of inflammatory disease models in 2015.This enzyme during the treatment of peri-implantitis along with other anti biotics was reported to be effective.

But scientifically speaking lot’s more need to be done, you can read some of the studies here;

Serrapeptase references

  1. Harris Interactive Over-The-Counter Pain Medication Study Sponsored by the National Consumers League. January 30, 2003. Chairman of Harris Poll, New York, NY: Humphrey Taylor. Contact: and
  2. Mazzone A, et al. Evaluation of serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res.; 1990; 18 (5); 379-88.
  3. Tachibana M, et al. A muti-centre, double-blind study of Serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica; 1984; 3(8); 526-30.
  4. Panagariya A, Sharma AK. A preliminary trial of Serratiopeptidase in patients with carpal tunnel syndrome. J Assoc Physicians India; 1999; 47 (12); 1170-1172.
  5. Kee WH, et al. The treatment of breast engorgement with Serrapeptase (Danzen): a randomized double-blind controlled trial. Singapore Med J.; 1989 30 (1); 48-54.
  6. Sasaki S, et al. Serrapeptase-induced lung injury manifesting as acute eosiniphilic pneumonia. Nihon Kokyuki Gakkai Zasshi. 2000; 38 (7); 540-4.

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