Nattokinase or Natto products are widely used throughout the world in capsule or tablet form as nutritional supplements in health promotion areas such as blood clot prevention, blood thinning and improved blood circulation. In this article we will examine in detail Nattokinase benefits and side effects, the health benefits of nattokinase,what Nattokinase is good for, is it safe to take and what is the correct Nattokinase dosage.
Where does Nattokinase come from?
Nattokinase is an enzyme derived from a staple Japanese food known as Natto, the Japanese make Natto from fermented soya beans it has been eaten there for more than 1,000 years. Significantly the heart disease risk of a person in Japan is about 1 in 9,000 compared to the Western world where the heart disease risk is one in 9.
Natto is produced during the fermentation process of the soya bean by adding the bacterium Bacillus natto to the soya after it has been boiled. The bacterium Bacillus acts on the soya beans to produce Natto.
We know that similar soy foods contain enzymes but the natto fermentation is the only enzyme to have the specific nattokinase enzyme. Nattokinase is a serine protease within the subtilisin family it is not a kinase even though it is in its name.
Nattokinase promotes strong fibrinolytic activity meaning it could digest fibroids. Nattokinase is manufactured in the main by three factories Daiwa Pharmaceutical, Contek Life Science and the Japanese Nattokinase Association in tandem with the Japan Bio Science Co.
Nattokinase scientific studies
Scientists have long engaged in a range of scientific studies of Nattokinase, as we speak there are continuous studies being evaluated as to the safety and efficacy of Nattokinase for human consumption.
During one study the results showed that Nattokinase B. nattoB-12 had some important effects on fibrinolytic activity meaning it is helpful in dissolving fibroids or plaque and reducing swelling in the body.
According to recent research not only does Nattokinase demonstrate potent fibrinolytic properties but it also displays anti-atherosclerotic, antihypertensive, anti-platelet neuroprotective effects and lipid lowering properties. This review deals with the primary pharmacological effects of Nattokinase with a focus on the clinical significance to Coronary Vascular Disease. It gives an outline on the key benefits to people with cardiovascular disease, the review goes so far as to say that Nattokinase is a promising alternative for the prevention and treatment of Coronary Heart Disease.
Furthermore, Nattokinase has numerous pharmacological properties not seen in other drugs or drug candidates, it is natural, it can be taken orally, it has been proven to be safe to take, it is relatively inexpensive, it is economical to use, overall Nattokinase has massive potential to be developed as a next generation non-drug for the treatment and prevention of CVD.
In this randomized study (September 23 rd. 2016) A group of 50 people were given 300mg Nattokinase supplement (100mg nattokinase & 200 mg maltodrexin) daily after a meal. In the same study 50 people were given a 300mg placebo capsule (300 mg maltodextrin) each day after the main meal.
Conclusions: We verified that nattokinase supplementation was associated with prolonged (C-EPI CT) the same effect as taking aspirin and aPTT in nondiabetic (lowering cholesterol), in people with borderline-to-moderate high cholesterol.
Is Nattokinase safe to take?
In a study of 100 non-demented people the investigators proposed to expose men and women to the Nattokinese supplement or to a placebo over a period of three years.
In a study (in vitro & in vivo) during 2005 by Omura K form from the Department of Legal Medicine, Dokkyo University School of Medicine, Tochigi, Japan it showed that NKCP had a fibrinolytic and antithrombotic effect like heparin, NKCP comes from food with data on safety demonstrated by preceding animal experts along with previous clinical trials, NKCP was considered safe to be used in a clinical setting.
Nattokinase drug interaction
Nattokinase should not be taken in conjunction with blood thinners.
Nattokinase side effects
Nattokinase is more than likely safe to take in the recommended dose, it does come from a food source and the Japanese people had consumed it for many years, don’t forget the Japanese have a 1 in 9000 chance of heart disease compared to the Western world stats of 1 in 9.Long term use of Nattokinase anywhere up to six months would seem to be safe also.
Warnings & Precautions
There isn’t enough research into taking Nattokinase whilst breastfeeding so use it with caution, for safety do not use.
Low blood pressure
Nattokinase has been shown to lower high blood pressure but be aware of what a normal blood pressure reading should be 120 over 80.Read our high blood pressure supplements review Click HERE.
Bleeding disorders: If you are prone to bleeding be aware that Nattokinase is a blood thinner and may make that condition worse. Be cautious about using.
Nattokinase and Surgery: If you are scheduled for surgery and you take Nattokinase regularly be cautious and stop taking it at a MINIMUM OF 2 WEEKS BEFOREHAND.
What health conditions can Nattokinase be used for?
Nattokinase has been proven to thin the blood helping to break up any formation of blood clots, this may protect against common health conditions such as heart disease, stroke (blood clots) and heart attack. Some of the research suggests that Nattokinase was effective in reducing blood pressure in patients taking the supplement every day for a period of 8 weeks.
In some earlier research people taking a combination of Nattokinase along with red yeast (a compound) during a six-month period showed good results in lowering cholesterol, however we haven’t found any evidence that by taking Nattokinase on its own will reduce cholesterol.
List of uses for Nattokinase
- Chronic fatigue
- Varicose veins
- Poor circulation
- High blood pressure
- PAD (peripheral artery disease)
- Fibroids in the uterus
If taking Nattokinase in capsule form for high blood pressure take the IU value of 140,000 – 250,000 once a day.
For heart disease take the maximum dose of 250,000 IU up to three times a day.
For inflammation, pain or swelling take the 140,000-250,000 IU Nattokinase up to three times a day.
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