What causes inflammation in the arteries

Arterial disease

What causes inflammation in the arteries?

What causes inflammation in the arteries? and what is the connection between Inflammation and Heart Disease. Heart disease is caused by a condition called atherosclerosis, it is a very serious disease characterized by chronic inflammation and fibrotic deterioration in the innermost layer of the medium and large arteries.

Basically, what happens is,when an injury occurs in the vascular wall the body produces inflammation in response to this attack, the major risk factors for developing cardiovascular disease (hypertension, smoking, diabetes,high cholesterol) are the primary cause of this injury.


The risks of inflammation

Inflammation is a common denominator in heart disease and stroke patients, inflammation is thought to be a signal of the promotion of fatty deposits in the arterial system. Though we have no proof that it causes cardiovascular disease it is rather important that we understand inflammation and its role in a healthy or unhealthy heart.

The main risk factors for heart disease are high blood pressure, cigarette smoking and bad cholesterol (LDL) these risks can cause injury to the heart. Following an injury to the arterial wall atherosclerosis or the accumulation of fatty deposits that stick to the inner wall of the arteries start to develop.

This build up leads to a narrowing of the arteries increasing the risk of a major blockage in the form of a heart attack or stroke.

We still need more research on how inflammation influences heart attacks and stroke, but it would seem that inflammation is the instigating event in many heart attacks and certain forms of stroke in fatty build-up and ldl cholesterol rich plaque in blood vessels.

From the research we know that inflammation plays a leading role when atherosclerosis becomes more advanced, lesions that form during this phase usually have no clinical symptoms until they regress and rupture. This process begins when extracellular lipids accumulate killing the cells in the centre of the plaque.

fatty deposit artery
fatty deposits

The body’s reaction to plaque build-up

Our bodies react to plaque build-up by trying to keep it away from the flow of blood, it sees the plaque as not normal and foreign or not belonging in the healthy blood vessels. This reaction is bringing inherent danger because the plaque may rupture if it comes away from the arterial wall and forms a dangerous clot. Most heart attacks and certain types stroke are mainly caused by the combination of formation of plaque and blood clots. If the blood flow to the artery leading to the heart is obstructed, it may cause a heart attack and if the blood flow to the brain is obstructed it may cause an ischemic stroke.

Lowering risk is crucial

For many years statins medications have been used to lower cholesterol, it is debatable whether the statins reduce inflammation or is it because of lowering cholesterol, the jury is still out on that one. There are several ongoing clinical trials testing other medications on lowering cholesterol in the arterial system to reduce the risks of a heart attack or stroke.


To summarize, inflammation does have a part to play during the whole atherosclerosis disease process, vascular lipid build-up is the main reason or cause of this inflammation. To limit the main risk factors and high cholesterol must be uppermost in people’s minds, we still await better treatment of the inflammation process which generally happens in response to damage to the endothelial wall of the artery.

A New Treatment

A new treatment that has shown promise in the approach to cardiovascular disease is the use of amino acid L-Arginine to help with the repair of the inflamed blood vessels, lower blood pressure and remove plaque build-up.

The best known of these supplemental food products is ProArgi 9+ the only L-Arginine with L-Citrulline found in the Physicians Reference Manual. People have used ProArgi 9 + and the reports and feedback have been good, Click here to read them.






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